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VOLUME 1 , ISSUE 3 ( July-September, 2022 ) > List of Articles

Clinicopathological Conference Report

Hypoxic–Ischemic Encephalopathy: To Cool, or Not to Cool, That Is the Question

Shabih Manzar, Ramachandra Bhat, Sheila Asghar, Rosario Riel–Romero, Nitin Walyat, Octavio Arevalo–Espejo, Maroun Mhanna

Keywords : Apgar, Bradypnea, Electroencephalogram, Gag reflex, Gestation, Infant, Neonatal, Newborn

Citation Information : Manzar S, Bhat R, Asghar S, Riel–Romero R, Walyat N, Arevalo–Espejo O, Mhanna M. Hypoxic–Ischemic Encephalopathy: To Cool, or Not to Cool, That Is the Question. 2022; 1 (3):320-326.

DOI: 10.5005/jp-journals-11002-0037

License: CC BY-NC 4.0

Published Online: 07-10-2022

Copyright Statement:  Copyright © 2022; The Author(s).


An infant was born at 38 weeks’ gestation. The assigned Apgar scores were 2, 3, and 5 at 1, 5, and 10 minutes, respectively. The physical examination showed hypotonia, absent gag reflex, and poor response to pain. At 9 hours after birth, the infant was noted to have a subtle seizure and bradypnea. The infant was intubated and started on anticonvulsant therapy. A brain magnetic resonance imaging (MRI) and an electroencephalogram (EEG) were obtained. This report presents the clinical and diagnostic dilemma that is typically associated with decisions needed for treatment with therapeutic hypothermia (TH).

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