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VOLUME 1 , ISSUE 1 ( January-March, 2022 ) > List of Articles


Rotavirus Infection in Neonates and Young Infants

Preeti Shakya, Biplov Adhikari, Amit S Nepal, Pragyik Pandey

Keywords : Diarrhea, Double-stranded ribonucleic acid, Gastroenteritis, Nonenveloped virus, Reovirus, Vaccine, World Health Organization

Citation Information : Shakya P, Adhikari B, Nepal AS, Pandey P. Rotavirus Infection in Neonates and Young Infants. 2022; 1 (1):142-150.

DOI: 10.5005/jp-journals-11002-0014

License: CC BY-NC 4.0

Published Online: 31-03-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Rotavirus is the primary cause of acute, frequently severe gastroenteritis among growing premature neonates, young infants, and children under the age of five globally. It contains a double-stranded ribonucleic acid genome is a member of the Reoviridae family. In this review, we have discussed the structure and characteristics of the virus, the pathogenesis of rotaviral diarrhea, clinical features, methods of diagnosis, clinical management, and available vaccines. This article combines peer-reviewed evidence from our own clinical studies with results of an extensive literature search in the databases PubMed, EMBASE, and Scopus.

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