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VOLUME 3 , ISSUE 2 ( April-June, 2024 ) > List of Articles


Concerns about Mis-/Overuse of Antibiotics in Neonates Born at ≤32 Weeks Gestational Age in Latin American Neonatal Units: Eight Years of Experience in the EpicLatino Database

Angela B Hoyos, Ariel Salas, Horacio Osiovich, Carlos A Fajardo, Martha Baez, Luis Monterrosa, Carolina Villegas-Alvarez, Fernando Aguinaga, Maria I Martinini

Keywords : Antibiotics per 1,000 patient-days, Antibiotic use practices, Baby, EpicLatino database, Infant, Latin America and the Caribbean, Mortality, Neonatal intensive care units, Neonatal outcomes, Neonates, Newborn, Premature neonates

Citation Information : Hoyos AB, Salas A, Osiovich H, Fajardo CA, Baez M, Monterrosa L, Villegas-Alvarez C, Aguinaga F, Martinini MI. Concerns about Mis-/Overuse of Antibiotics in Neonates Born at ≤32 Weeks Gestational Age in Latin American Neonatal Units: Eight Years of Experience in the EpicLatino Database. 2024; 3 (2):83-89.

DOI: 10.5005/jp-journals-11002-0098

License: CC BY-NC 4.0

Published Online: 21-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


There is considerable variability in the duration of antibiotic in neonatal intensive care units (NICUs) all over the world and is highly dependent on gestational ages (GA). It is difficult to withhold antibiotics in critically ill preterm infants because the possibility of infection is difficult to exclude in these patients and the acuity of illness can progress rapidly with potentially disastrous consequences. Available data encouragingly suggest that the incidence of early onset sepsis (EOS) might be lower in EpicLatino units in Latin America compared with Canadian research network (CNN) in 2022 in <30 weeks, but late onset sepsis (LOS) is more frequent at different GA. However, there is an overall scarcity of detailed information from many countries. The annual reports from EpicLatino database do show a high degree of variability in outcomes and a need for cautious interpretation of these figures. However, we still need to establish clear standards for antibiotic use in premature infants; these drugs are essential for combating infections and saving lives but mis-/overuse can exacerbate the risk of late-onset infections, necrotizing enterocolitis (NEC), bacterial resistance, and increase the cost of care. In this study, we aimed to find information on the patterns of antibiotic use in infants born at ≤32 weeks’ gestation in the EpicLatino units during the period 2015–2022. A specifically designed questionnaire was sent to unit medical directors to determine whether the total antibiotic use per unit per 1,000 patient-days correlated with the incidence-rate ratios. This is a data-collecting/descriptive study that it will help us in designing further efforts and choosing the sites for intervention.

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