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VOLUME 3 , ISSUE 1 ( January-March, 2024 ) > List of Articles


Comparison of Transcutaneous Bilirubin with Total Serum Bilirubin Levels Before, During, and Post-phototherapy in Preterm and Term Newborns in Uttarakhand, India

Ravi Sahota, Virender Singh, Heena Parveen, Navpreet Kaur, Neha Upreti, Abhay Mahindre, Bharat Bhushan Gupta

Keywords : Bilirubin, Newborn, Phototherapy, Transcutaneous bilirubin, Total serum bilirubin

Citation Information : Sahota R, Singh V, Parveen H, Kaur N, Upreti N, Mahindre A, Gupta BB. Comparison of Transcutaneous Bilirubin with Total Serum Bilirubin Levels Before, During, and Post-phototherapy in Preterm and Term Newborns in Uttarakhand, India. 2024; 3 (1):8-12.

DOI: 10.5005/jp-journals-11002-0086

License: CC BY-NC 4.0

Published Online: 26-03-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Background: Neonatal jaundice, although generally benign, can pose a significant threat to a select number of newborns, potentially resulting in severe brain damage or even death. Objectives: To compare the transcutaneous bilirubin (TCB) with total serum bilirubin (TSB) levels before, during the phototherapy on a covered definite spot of skin and after 2 days of post-phototherapy in preterm and term newborns. Materials and methods: A total of 272 babies, who had jaundice, admitted to NICU of Sahota Superspeciality Hospital, Kashipur, Uttarakhand, India, were enrolled in the study during the period March 2018 to February 2020. Transcutaneous bilirubin and TSB were done in all the babies and compared before starting phototherapy, during phototherapy, and after 48 hours of stopping the phototherapy. Results: Before phototherapy (PT)-TCB showed statistically significant positive correlation with before PT-TSB. During PT-TCB showed statistically significant positive correlation with PT-TSB. After PT-TCB showed statistically significant positive correlation. Bilirubin level measured by TCB and TSB method was statistically significantly comparable before, during, and after PT (p > 0.05). Conclusion: There is a significant positive correlation between TCB and TSB in preterm and term newborns who required phototherapy for hyperbilirubinemia, before starting the phototherapy, during phototherapy, and after 48 hours of its stoppage. Clinical significance: Transcutaneous bilirubin is a good tool to do screening for hyperbilirubinemia. TCB can be used as a noninvasive tool to assess bilirubin during and after phototherapy.

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  1. Woodgate P, Jardine LA. Neonatal jaundice: Phototherapy. BMJ Clin Evid 2015;2015:0319. PMID: 25998618.
  2. Lauer BJ, Spector ND. Hyperbilirubinemia in the newborn. Pediatr Rev 2011;32(8):341–349. DOI: 10.1542/pir.32-8-341.
  3. Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. Can Med Assoc J 2006;175(6):587–590. DOI: 10.1503/cmaj.060328.
  4. Ebbesen F, Andersson C, Verder H, et al. Extreme hyperbilirubinaemia in term and near-term infants in Denmark. Acta Paediatrica 2005;94(1):59–64. DOI: 10.1111/j.1651-2227.2005.tb01789.x.
  5. Taylor JA. Discrepancies between transcutaneous and serum bilirubin measurements. Pediatrics 2015;135(2):224–231. DOI: 10.1542/peds.2014-1919.
  6. Bhutani VK, Zipursky A, Blencowe H, et al. Neonatal hyperbilirubinemia and rhesus disease of the newborn: Incidence and impairment estimates for 2010 at regional and global levels. Pediatr Res 2013;74 Suppl 1(Suppl 1):86–100. DOI: 10.1038/pr.2013.208.
  7. Grupp-Phelan J, Taylor JA, Liu LL, et al. Early newborn hospital discharge and readmission for mild and severe jaundice. Arch Pediatr Adolesc Med 1999;153(12):1283–1288. DOI: 10.1001/archpedi.153.12.1283.
  8. Ministry of Health Malaysia. Clinical practice guidelines: Management of neonatal jaundice. 2nd ed. Kuala Lumpur, Malaysia: Ministry of Health; 2014.
  9. Mohamed M, Ibrahim NR, Ramli N, et al. Comparison between the transcutaneous and total serum bilirubin measurement in Malay neonates with neonatal jaundice. Malays J Med Sci 2022;29(1):43–54. DOI: 10.21315/mjms2022.29.1.5.
  10. Tan KL, Dong F. Transcutaneous bilirubinometry during and after phototherapy. Acta Paediatr 2003;92:327–331. PMID: 12725548.
  11. Nagar G, Vandermeer B, Campbell S, et al. Effect of phototherapy on the reliability of transcutaneous bilirubin devices in term and near-term infants: A systematic review and meta-analysis. Neonatology 2016;109(3):203–212. DOI: 10.1159/000442195.
  12. Casnocha LL, Matasova K, Zibolen M, et al. Accuracy of transcutaneous bilirubin measurement in newborns after phototherapy. J Perinatol 2016;36(10):858–861. DOI: 10.1038/jp.2016.91.
  13. Johnson SM, Vasu V, Marseille C, et al. Validation of transcutaneous bilirubinometry during phototherapy for detection and monitoring of neonatal jaundice in a low-income setting. Paediatr Int Child Health 2020;40(1):25–29. DOI: 10.1080/20469047.2019.1598126.
  14. Radfar M, Hashemieh M, Shirvani F, et al. Transcutaneous bilirubinometry in preterm and term newborn infants before and during phototherapy. Arch Iran Med 2016;19(5):323–328. PMID: 27179163.
  15. Hassan Shabuj M, Hossain J, Dey S. Accuracy of transcutaneous bilirubinometry in the preterm infants: A comprehensive metaanalysis. J Matern Fetal Neonatal Med 2019;32(5):734–741. DOI: 10.1080/14767058.2017.1390561.
  16. Vasava S, Dagli P. Transcutaneous bilirubinometry: Influence of gestational age and measurement site. Sri Lanka J Child Health 2018;47:27–32. DOI: 10.4038/SLJCH.V47I1.8426.
  17. Amneenah A. Comparison of diagnostic accuracy of transcutaneous bilirubinometry during phototherapy by using skin patch. Int J Health Sci 2022;6:7276–7288. DOI: 10.53730/ijhs.v6nS2.6779.
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