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VOLUME 2 , ISSUE 2 ( April-June, 2023 ) > List of Articles


Importance of Neuroimaging in Infants with Microcephaly

Sabrina Rangwani, Gunes Orman, Maroun Mhanna, Thierry AGM Huisman

Keywords : Aminoacylase-2, Apert, Brain volume, Brain volume loss, Canavan's disease, Cavum septum pellucidum, child abuse, Crouzon, cytomegalovirus, Ex vacuo enlargement of ventricles, Head circumference, Meckel-Gruber syndrome, Melting brain, near-drowning, Neuroimaging, Skull deformities, Thalami, TORCH, Toxoplasma gondii, Trisomy 13, Trisomy 18, Trisomy 21, Twin-to-twin transfusion syndrome, Vein of Galen aneurysmal malformation, Zika virus, Zika

Citation Information : Rangwani S, Orman G, Mhanna M, Huisman TA. Importance of Neuroimaging in Infants with Microcephaly. 2023; 2 (2):148-157.

DOI: 10.5005/jp-journals-11002-0065

License: CC BY-NC 4.0

Published Online: 05-07-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Microcephaly is diagnosed in infants and children with a head circumference (HC) 2 standard deviations less than average, accounting for age and gender. There is not a standard method of diagnosis, as growth charts vary by country and methodology used. The most popular method of diagnosis is the use of a tape to measure a child's head. There are various conundrums that affect diagnoses: volume of the brain, deformities in skull shape that affect size measurements, and the etiology of microcephaly. The size of the skull is not the most important factor in diagnosing microcephaly, but rather the volume of the brain. Finally, a distinction between primary and secondary microcephaly must be made; primary microcephaly develops prenatally, and secondary microcephaly develops postnatally. The effects of primary microcephaly are generally more severe, but through imaging, it can be detected before birth. This article analyzes various conditions in which neuroimaging can add considerable information to current methods of clinical evaluation. There is a clear need for a multifaceted approach.

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