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VOLUME 2 , ISSUE 1 ( January-March, 2023 ) > List of Articles

REVIEW ARTICLE

Congenital Chikungunya Virus Infections

Astha Amrit, Sushant Mane, Gangajal Kasniya, Mohd Mozibur Rahman, Atnafu Mekonnen Tekleab

Keywords : Aedes aegypti, Aedes albopictus, Brownie nose, Chikungunya sign, Chikungunya virus encephalitis, Infant, Neonate, Newborn, Thrombocytopenia, Vertical transmission

Citation Information : Amrit A, Mane S, Kasniya G, Rahman MM, Tekleab AM. Congenital Chikungunya Virus Infections. 2023; 2 (1):45-59.

DOI: 10.5005/jp-journals-11002-0054

License: CC BY-NC 4.0

Published Online: 07-04-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Structure: Chikungunya virus (CHIKV) is an arthropod-borne ribonucleic acid (RNA) virus, classified in the genus alphavirus in the family Togaviridae. Clinical presentation: Perinatal/neonatal infections are rare, but some infants can develop fever, thrombocytopenia, lymphopenia, pigmentary changes, and a maculopapular rash. The neurocognitive outcome of some infants with vertically transmitted mother-to-child perinatal infections and CHIKV neonatal encephalopathy can be poor. Diagnosis: The diagnosis of CHIKV infections can be confirmed by the detection of chikungunya viral RNA via real-time reverse-transcription polymerase chain reaction (RT-PCR) and/or specific immunoglobulin (Ig)M and IgG serology. Treatment: Currently, no specific antiviral treatment(s) are available for CHIKV, and management is limited to supportive care by maintaining adequate intravascular volume by intravenous fluids and oral rehydration. Infants exposed in utero or during the perinatal period need to be monitored for adverse neurocognitive outcomes.

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