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VOLUME 1 , ISSUE 1 ( January-March, 2022 ) > List of Articles

REVIEW ARTICLE

Role of the Endothelium in Neonatal Diseases

Olachi J Mezu-Ndubuisi, Akhil Maheshwari

Keywords : Angiogenesis, Bronchopulmonary dysplasia, Endothelium, Necrotizing enterocolitis, Neonate, Retinopathy of prematurity

Citation Information : Mezu-Ndubuisi OJ, Maheshwari A. Role of the Endothelium in Neonatal Diseases. 2022; 1 (1):44-57.

DOI: 10.5005/jp-journals-11002-0025

License: CC BY-NC 4.0

Published Online: 31-03-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

In both fetal and neonatal physiologic and pathologic processes in most organs, endothelial cells are known to play critical roles. Although the endothelium is one of the most ubiquitous cell type in the body, the tight adherence to the blood vessel wall has made it difficult to study their diverse function and structure. In this article, we have reviewed endothelial cell origins and explored their heterogeneity in terms of structure, function, developmental changes, and their role in inflammatory and infectious diseases. We have also attempted to evaluate the untapped therapeutic potentials of endothelial cells in neonatal disease. This article comprises various peer-reviewed studies, including ours, and an extensive database literature search from EMBASE, PubMed, and Scopus.


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